Zinc Finger nucleases (ZFNs) use a DNA binding motif called a zinc finger (because of its shape, and because it contains, you guessed it, Zinc). These zinc fingers have been engineered to bind the 64 unique three amino acid sequences that can be found in DNA. So one would simple have to identify the sequence in the DNA where they want to cut, and create the appropriate sequence of zinc finger domains to match the sequence (see image)..
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